C чего лучше начинать монотерапию артериальной гипертензии?
Согласно выводам большого ретроспективного исследования, опубликованного в The Lancet, диуретики являются более эффективным и безопасным методом лечения, чем ингибиторы ангиотензинпревращающего фермента (АПФ) для пациентов, начинающих монотерапию артериальной гипертензии.
Используя девять баз данных здравоохранения США, Германии, Японии и Южной Кореи, исследователи изучили почти 5 миллионов пациентов, которые начали лечение одним из антигипертензивных препаратов. Большинство сравнений эффективности по классам медикаментов не показали существенных различий. Однако по сравнению с ингибиторами АПФ приём тиазидных диуретиков показал снижение (примерно на 15%) риска госпитализации по поводу сердечной недостаточности, а также риска возникновения у пациентов инфаркта миокарда или инсульта.
Источник: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32317-7/fulltext
Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis.
Suchard MA et al
BACKGROUND:
Uncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in the absence of comorbid indications. Randomised trials have not further refined this choice.
METHODS:
We developed a comprehensive framework for real-world evidence that enables comparative effectiveness and safety evaluation across many drugs and outcomes from observational data encompassing millions of patients, while minimising inherent bias. Using this framework, we did a systematic, large-scale study under a new-user cohort design to estimate the relative risks of three primary (acute myocardial infarction, hospitalisation for heart failure, and stroke) and six secondary effectiveness and 46 safety outcomes comparing all first-line classes across a global network of six administrative claims and three electronic health record databases. The framework addressed residual confounding, publication bias, and p-hacking using large-scale propensity adjustment, a large set of control outcomes, and full disclosure of hypotheses tested.
FINDINGS:
Using 4·9 million patients, we generated 22 000 calibrated, propensity-score-adjusted hazard ratios (HRs) comparing all classes and outcomes across databases. Most estimates revealed no effectiveness differences between classes; however, thiazide or thiazide-like diuretics showed better primary effectiveness than angiotensin-converting enzyme inhibitors: acute myocardial infarction (HR 0·84, 95% CI 0·75-0·95), hospitalisation for heart failure (0·83, 0·74-0·95), and stroke (0·83, 0·74-0·95) risk while on initial treatment. Safety profiles also favoured thiazide or thiazide-like diuretics over angiotensin-converting enzyme inhibitors. The non-dihydropyridine calcium channel blockers were significantly inferior to the other four classes.
INTERPRETATION:
This comprehensive framework introduces a new way of doing observational health-care science at scale. The approach supports equivalence between drug classes for initiating monotherapy for hypertension-in keeping with current guidelines, with the exception of thiazide or thiazide-like diuretics superiority to angiotensin-converting enzyme inhibitors and the inferiority of non-dihydropyridine calcium channel blockers.
FUNDING:
US National Science Foundation, US National Institutes of Health, Janssen Research & Development, IQVIA, South Korean Ministry of Health & Welfare, Australian National Health and Medical Research Council.