Альбутерол при тонзиллэктомии у детей.
Рандомизированное плацебо-контролируемое исследование почти у 480 детей, перенесших тонзиллэктомию, показало, что превентивное применение альбутерола снижало частоту возникновения периоперационных респираторных осложнений, включая ларингоспазм, кашель и кислородную десатурацию.
Однако, для того чтобы рекомендовать альбутерол для всех пациентов, необходимы дополнительные исследования. Тем не менее результаты данного исследования подтверждают, что однократное применение альбутерола перед тонзиллэктомией, снижает риск возникновения респираторных осложнений в периоперационном периоде у детей, страдающих астмой, средней тяжести или тяжёлой формой обструктивного апноэ во сне, а также у детей, недавно перенесших инфекцию верхних дыхательных путей.
Источник: JAMA Pediatr. 2019 Apr 22. doi: 10.1001/jamapediatrics.2019.0788. [Epub ahead of print]
Effect of Albuterol Premedication vs Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: The REACT Randomized Clinical Trial.
von Ungern-Sternberg BS et al
IMPORTANCE:
Tonsillectomy is a common pediatric procedure for the treatment of sleep-disordered breathing and chronic tonsillitis. Up to half of children having this procedure experience a perioperative respiratory adverse event.
OBJECTIVE:
To determine whether inhaled albuterol sulfate (salbutamol sulfate) premedication decreases the risk of perioperative respiratory adverse events in children undergoing anesthesia for tonsillectomy.
DESIGN, SETTING, AND PARTICIPANTS:
A randomized, triple-blind, placebo-controlled trial (the Reducing Anesthetic Complications in Children Undergoing Tonsillectomies [REACT] trial) was conducted at Perth Children's Hospital (formerly Princess Margaret Hospital for Children), the only tertiary pediatric hospital in Western Australia. Participants included 484 children aged 0 to 8 years who were undergoing anesthesia for tonsillectomy. The study was conducted between July 15, 2014, and May 18, 2017.
INTERVENTIONS:
Participants were randomized to receive either albuterol (2 actuations, 200 μg) or placebo before their surgery.
MAIN OUTCOMES AND MEASURES:
Occurrence of perioperative respiratory adverse events (bronchospasm, laryngospasm, airway obstruction, desaturation, coughing, and stridor) until discharge from the postanesthesia care unit.
RESULTS:
Of 484 randomized children (median [range] age, 5.6 [1.6-8.9] years; 285 [58.9%] boys), 479 data sets were available for intention-to-treat analysis. Perioperative respiratory adverse events occurred in 67 of 241 children (27.8%) receiving albuterol and 114 of 238 children (47.9%) receiving placebo. After adjusting for age, type of airway device, and severity of obstructive sleep apnea in a binary logistic regression model, the likelihood of perioperative respiratory adverse events remained significantly higher in the placebo group compared with the albuterol group (odds ratio, 2.8; 95% CI, 1.9-4.2; P < .001). Significant differences were seen in children receiving placebo vs albuterol in laryngospasm (28 [11.8%] vs 12 [5.0%]; P = .009), coughing (79 [33.2%] vs 27 [11.2%]; P < .001), and oxygen desaturation (54 [22.7%] vs 36 [14.9%]; P = .03).
CONCLUSIONS AND RELEVANCE:
Albuterol premedication administered before tonsillectomy under general anesthesia in young children resulted in a clinically significant reduction in rates of perioperative respiratory adverse events compared with the rates in children who received placebo. Premedication with albuterol should be considered for children undergoing tonsillectomy.